In the light of the previous report that miR-552-3p regulates the transcriptional activity of nuclear receptor subfamily 1 (NR1) including FXR, LXRα and PPARγ which participate in the liver fibrosis and inflammation processes by promoting the transformation of HSCs27, we firstly examined the effect of miR-552-3p on the mRNA levels of fibrotic and inflammatory genes under the condition of agonist or antagonist of FXR, LXRα and PPARγ14. Here, NR1H3 is linked to Hepatic fibrosis.