ZIC2 can transcriptional regulates Src, lncRNA SNHG12, Axin2, Runx2, OCT4, STAT3, PAK4 expression in non-small cell lung cancer, endometrial cancer, colon cancer, ccRCC, lung adenocarcinoma, liver cancer, and breast cancer 15, 28, 36-41. The gene discussed is PAK4; the disease is nonpapillary renal cell carcinoma.