On the other hand, in advanced stages and under certain conditions, mechanisms may allow for P2X7 receptor activation through altered regulatory proteins, repair processes, and interactions between mediators such as MMPs and ectonucleosides leading to increased concentrations of ATP, increased purinergic signaling, and accelerated local inflammation contributing to the AMD pathogenesis. The gene discussed is P2RX7; the disease is age-related macular degeneration.