Like other mechanisms of NLRP3 inflammasome activation, AβO-induced AMD models have been demonstrated to result in the expression of GSDMD (Sun et al., 2018), along with RPE cytotoxicity driven by mitochondrial dysfunction and ROS formation (Sorbara and Girardin, 2011; Zhou et al., 2011). Here, NLRP3 is linked to age-related macular degeneration.