NLRP3 and age-related macular degeneration: Based on the mechanisms described above, activation of the NLRP3 inflammasome and various gasdermin proteins have been implicated in the pathogenesis of AMD and several pathways have been suggested to trigger inflammasome activation in the outer retina including lipofuscin component A2E, accumulated Alu RNA, drusen components, amyloid-β, lipid peroxidation products, photooxidative damage, lysosomal destabilizations, particulate matter, overexpression of VEGF, and eATP (Ambati et al., 2013; Kerur et al., 2013).