REN and hydrops fetalis: A machine learning phenotypic analysis of clinically distinct subgroups found that spironolactone has a pronounced improvement in death and HF hospitalization in patient phenotype subgroup that demonstrated more functional impairment, obesity, diabetes, chronic kidney disease, concentric LV hypertrophy, high renin, and biomarkers of tumor necrosis factor-alpha-mediated inflammation, liver fibrosis, and tissue remodeling [158].