ACAN and schizophrenia: For example, a few studies show that administration of Poly I:C during pregnancy, a strategy often used to model schizophrenia, results in reduced aggrecan staining in the hippocampus (Wegrzyn et al., 2021; Mao et al., 2022), and in a similar model, Paylor et al. (2016) described a reduction in WFA staining in the prefrontal cortex of the adult offspring.