STAT1 and breast cancer: A study showed that gMG treatment significantly retards tumor growth, reduces CAF production, and improves DOX sensitivity in a DOX-resistant TNBC tumoroid-bearing mouse model, because it was found that INFG/STAT1/NOTCH3 is a molecular link between breast cancer stem cells and CAFs, and it’s expression was increased in DOX-resistant TNBC cell lines, as well as CAF-transformation and self-renewal ability (182).