GOLPH3 and ductal breast carcinoma in situ: An IHC study of 449 patients with DCIS who had undergone extensive resection and did not receive radiotherapy and chemotherapy concluded that FAP-α and GOLPH3 overexpression were highly specific for the recurrence and progression of DCIS and may thus represent novel tumor markers for progression of DCIS to invasive breast cancer (IDC) (155).