But the majority of tumor stroma in ductal carcinoma in situ(DCIS) and invasive breast cancer of no special type (IBC-NST) were characterized by α-SMA positive myofibroblasts rather than CD34+ fibroblasts, several CD34+ fibroblasts are preserved in invasive lobular carcinomas (ILC) (34). The gene discussed is ACTA1; the disease is ductal breast carcinoma in situ.