EGFR and breast carcinoma: Another study showed that low expression of CAV-1 in breast cancer stroma was associated with early recurrence, progression, tamoxifen resistance, and 5-year survival, especially in invasive micropapillary carcinoma, whereas CAV-1 gene expression promoted EGFR signal transduction, which mediates tyrosine kinase activity and was found to be an effective marker for breast cancer diagnosis and prognosis (164).