Another study showed that low expression of CAV-1 in breast cancer stroma was associated with early recurrence, progression, tamoxifen resistance, and 5-year survival, especially in invasive micropapillary carcinoma, whereas CAV-1 gene expression promoted EGFR signal transduction, which mediates tyrosine kinase activity and was found to be an effective marker for breast cancer diagnosis and prognosis (164). This evidence concerns the gene CAV1 and breast carcinoma.