By designing a plasmid that connects mucosal vascular addressin cell adhesion molecule-1 (MAdCAM-1) extracellular D1 and D2 domains to an Fc region of rat IgG which was then conjugated to an LNP PEG chain using thiol–maleimide chemistry, the authors were able to successfully target the gut environment with high specificity to alleviate inflammatory bowel disease (IBD). The gene discussed is MADCAM1; the disease is inflammatory bowel disease.