Since we mainly considered the role and possible mechanism of serum hsa_circ_0072309 in BM arising from NSCLC, we primarily analyzed whether ALK gene mutation affected the prognosis of NSCLC BM+ patients and whether it was related to serum hsa_circ_0072309/miR‐100/ACKR3 axis. This evidence concerns the gene ACKR3 and non-small cell lung carcinoma.