While ALS is generally considered to specifically affect motor neurons, 32% of ALS patients have sensory impairment, and there are reports of axonal and demyelinating degeneration on peroneal nerve biopsy [28] and abnormal TDP-43 expression in cortical, subcortical, and thalamic areas, including sensory areas, on autopsy [29], indicating that sensory neurons in addition to motor neurons may degenerate [30, 31]. This evidence concerns the gene TARDBP and Somatic sensory dysfunction.