TDP-43 mislocalization from the nucleus to the cytoplasm is more common in neurons than in other cells in ALS [42], and the half-life of mutant TDP-43 is longer than that of WT TDP-43 [5], suggesting that alterations in TDP-43 function may enhance motor neuron vulnerability in ALS. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.