TARDBP and amyotrophic lateral sclerosis: Seven TDP-43 mutants (G298S, A315T, M337V, Q343R, G348C, N352S, and A382T) were previously used to examine the relationship between TDP-43 half-life and age at onset of ALS, and the findings revealed that mutants with a longer half-life resulted in an earlier age at onset, i.e., there was a negative correlation between half-life and age at onset [5].