KLK3 and posterior cortical atrophy: Moreover, when multi-round PSA tests were available, the participants can be further reclassified into four subgroups with FR(−)/LR(−), FR(+)/LR(−), FR(−)/LR(+) and FR(+)/LR(+), and the risk of PCa was significantly higher for any subgroups with positive PSA [including FR(+)/LR(−), FR(−)/LR(+) and FR(+)/LR(+)] compared with those with FR(−)/LR(−).