Additionally, although there was no difference in the proportions of high-grade PCa between optimized screening strategy two and three (P = 0.967), the proportion of false-positive PSA in optimized strategy three was significantly lower than that in optimized strategy two (8.8% vs. 45.2%, P < 0.001) (Fig. 3B). The gene discussed is KLK3; the disease is posterior cortical atrophy.