Recent application of molecular techniques has identified numerous lesions with distinctive genetic abnormalities and clinicopathological characteristics [7], for instance, JAZF1::SUZ12 fusion in LG-ESS, YWHAE::NUTM2 fusion and ZC3H7B::BCOR fusion in HG-ESS, and DICER1 mutations in embryonal RMS. The gene discussed is JAZF1; the disease is endometrioid stromal sarcoma.