On the other hand, pancreatitis could cause fluctuations in blood glucose, and mechanisms may lie in: first, stress hyperglycemia that mainly occurs in the early stage of onset, and a variety of inflammatory factors stimulate the increase in the release of glucagon, glucocorticoid, and other hyperglycemic hormones; second, microcirculation disturbance of pancreatic tissue characterized by edema, ischemia, and necrosis that result in destruction of islets, after which a large amount of insulin release and insufficient nutrition can lead to hypoglycemia. This evidence concerns the gene INS and Hypoglycemia.