In case of obesity and diabetes, inhibition of the NF-κB signaling pathway ameliorates disturbances in mitochondrial respiratory function/morphology, decreases the expression of key mitochondrial genes such as SDHA, ANT-1, UCP3, and MFN2, and attenuates the increase of ROS and the decrease of insulin sensitivity of myotubes [132]. This evidence concerns the gene MFN2 and obesity due to melanocortin 4 receptor deficiency.