HMGB1 and migraine disorder: Finally, we could show, in WT mice, that the systemic administration prior to CSD induction of an inhibitor of Panx1 mega-channels, which are activated by neuronal stressors, such as CSD and induce a neuroinflammatory cascade [12], prevented not only the increased MGS scores and oculotemporal head grooming strokes behavioural phenotypes but also the enhanced neuroinflammatory HMGB1 release phenotype suggests that modulation of Panx1 may be a promising avenue to treat migraine.