In patients with AD-CBS and typical AD, we observed a significant explanation of regional TSPO-PET by Aβ-PET (AD-CBS: βA = 0.131 ± 0.186 / p < 0.001 in 64% of individuals; AD: βA = 0.142 ± 0.123 / p < 0.001 in 33% of individuals) and tau-PET (AD-CBS: βT = 0.385 ± 0.176 / p < 0.001 in 82% of individuals; AD: βT = 0.412 ± 0.196 / p < 0.001 in 83% individuals; Fig. 2B/C), but explanation by perfusion and GMVs did again not exceed the level of controls (Supplemental Fig. 1). Here, TSPO is linked to Alzheimer disease.