Since ADAM12 mediates cell–cell communication—i.e., by shedding growth factors and cytokines of the cell surface as well as through interactions with integrins [7, 8, 30] - and similarly to ADAM10, ADAM12 expression is induced by ionizing radiation, its indicates that ADAM12 could impact the cancer response to RT by remodeling the TME. Here, ADAM10 is linked to cancer.