Subgroup analyses showed that R-CHOP compared to R-FC in MCL Elderly (median OS 1.1 vs. 2.3 years; HR 3.61 vs. 3.50) as well as R-CHOP/R-DHAP induction compared to R-CHOP induction in MCL Younger (median OS 1.5 vs. 5.6 years; HR 5. The gene discussed is DDIT3; the disease is mantle cell lymphoma.