We show that de-regulated promoters and enhancers in IDH2R140Q AML cells are enriched for specific transcription factors motifs that form an AML-IDH subtype specific network, including RUNX, STAT5, OCT, IRF, PU.1, AP-1 (FOS, JUN), ETS and MYC. Here, SPI1 is linked to acute myeloid leukemia.