We show that de-regulated promoters and enhancers in IDH2R140Q AML cells are enriched for specific transcription factors motifs that form an AML-IDH subtype specific network, including RUNX, STAT5, OCT, IRF, PU.1, AP-1 (FOS, JUN), ETS and MYC. The gene discussed is FOS; the disease is acute myeloid leukemia.