The results showed that Ang-2 levels had the highest predictive ability for overall survival (OS) in HCC patients, Ang-2 and alpha-fetoprotein (AFP) levels were independent factors for PFS, and Ang-2 was better than Ang-1 or VEGF as a prognostic biomarker for HCC, especially after local therapy. Here, VEGFA is linked to hepatocellular carcinoma.