In KU873, for example, a DCIS clone (in no. 3) had two driver mutations in GATA3 and CBFB in addition to der(1;16) and a PTEN mutation, whereas no additional driver mutations were found in the remaining seven non-cancer lesions except for no. 8 carrying a GATA3 mutation (Extended Data Fig. 5b). The gene discussed is CBFB; the disease is ductal breast carcinoma in situ.