AKT1 and ductal breast carcinoma in situ: Because these cancer and non-cancer lesions shared many driver alterations, in addition to der(1;16) and an AKT1 mutation, and had an identical germline background, WGS of these lesions provides a unique opportunity to investigate the critical genetic events that discriminate among IDC, DCIS, non-cancer proliferative lesions and histologically normal lobules.