Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza pathway was found to be significantly upregulated in the severe group’s monocytes with DEGs of AREG, CCL3, CCL4, CXCL8, IL1B, and ISG15 (coverage = 7% and p < 0.001). This evidence concerns the gene ISG15 and influenza.