Using KEGG analysis, 157 enriched pathways were identified and the top 20 pathways according to FDR value are shown in Fig. 3B. These included pathways associated with cancer, focal adhesion, diabetic cardiomyopathy, and the PI3K/AKT, VEGF, Ras, and MAPK signaling pathways. The gene discussed is AKT1; the disease is diabetic cardiomyopathy.