H19 and colorectal cancer: For instance, in glioblastoma tumorigenesis, HDAC2 knockdown has been shown to impede tumor-sphere formation and proliferation by upregulating miR-3189-mediated GLUT335.In contrast, HDAC2 functions as a metastasis suppressor in colorectal cancer by impeding EMT and the expression of H19 and MMP1436.