It was shown that the AuNCs-LHRHa nanosystem was effectively recognized by the gonadotropin-releasing hormone receptor on the RM-1 cell (a murine prostate cancer cell derived from C57BL/6 mice) membrane, which enhanced the tumor cell uptake of the nanosystem, thereby improving the targeting accuracy and PTT effect of prostate cancer. The gene discussed is GNRHR; the disease is prostate cancer.