IL6 and infection: Both the upper and lower airways responded to the infection by all VoCs (Fig. 2C, D), but with a tissue-specific inflammatory signature: in the lungs, Mx2, Il-6, Cxcl10 and Il-10 were upregulated for all VoCs, and the highest in SARS-COV-2 Wuhan-infected animals (Fig. 2C).