Here, we analyzed the role of human TLR8 in a mouse lupus model expressing a human TLR8 BAC transgene (huTLR8tg) that confers low-level huTLR8 expression, insufficient to cause spontaneous inflammation in non-autoimmune mice (Guiducci et al, 2013). This evidence concerns the gene TLR8 and systemic lupus erythematosus.