In the case of LPS, collapse of BM EMBIs is MyD88-dependent but independent of inflammatory cytokines including TNF, IL1 and G-CSF (Bisht et al, 2020; Lévesque et al, 2021); these findings are consistent with the known signaling of huTLR8 through MyD88 and our own unpublished observation that anemia is TNF-independent in our model. The gene discussed is MYD88; the disease is anemia (phenotype).