TLR5 and Splenomegaly: Accordingly, we observed splenomegaly (Fig S3A), expansion of the red pulp (Figs 2D and E and S4I compared with Fig S4F–H), and increased terminal erythroid differentiation in the spleens of anemic huTLR8tg.Sle1.Yaa mice (Figs 2F and G and S4A, C, and D).