EGFR and non-small cell lung carcinoma: As expected, most EGFR interactors displayed similar organelle distributions in cytosol and plasma membrane across four NSCLC cell lines, while the proteasome-related proteins were only enriched in the NSCLC cells possessing EGFR Del19 mutations and the EGFR-L858R interacted with more nuclear and lysosomal proteins (Fig. 2B).