Functionally, higher methyltransferase-like protein-1/WDR4 levels enhance the levels of m7G-modified tRNAs (e.g., tRNAAGCAla, tRNACGCAla, tRNAUGCAla, tRNAUCUArg, tRNAGUUAsn, tRNAGCACys, tRNAAAUIle, tRNACUULys, tRNAUUULys, tRNACAUMet, tRNAUGUThr, tRNACCATrp, tRNAGUATyr, tRNAAACVal, tRNACACVal, and tRNAUACVal), which promote hepatocellular carcinoma proliferation, migration, and invasion (160). This evidence concerns the gene WDR4 and hepatocellular carcinoma.