Current evidence does not support the role of placental “cancer-like invasion” on the pathophysiology of CSP/PAS9; Instead, the shared histopathology between CSP and PAS has been already demonstrated,11and recent prospective studies12, 13support the primary role of an abnormal implantation into a previously scarred myometrium, its progressive dehiscence and uterine remodeling as the proxy for the continuum between CSP and PAS. Here, DNAJC5 is linked to cancer.