The lower pathogen load in the lungs of WildR mice at 14 days post-infection did not translate into a measurable difference in pulmonary histopathology including the number of lesions and their organization and the absolute numbers of CD4 and CD8 T cells in our studies correlated with the organ bacterial load rather than the microbiome changes (Figs 3 and 4). Here, CD8A is linked to infection.