Similarly, the shared signaling pathways between obesity and major depressive disorder in both analyses are: Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Transmission across Chemical Synapses (R-HSA-112315), Neuronal System (R-HSA-112316), Axon guidance (R-HSA-422475), Developmental Biology (R-HSA-1266738), Cardiac conduction (R-HSA-5576891), Phase 0—rapid depolarisation (R-HSA-5576892), SALM protein interactions at the synapse (R-HSA-8849932), Signaling by ERBB4 (R-HSA-1236394). Here, ERBB4 is linked to major depressive disorder.