CXCL8 and chronic obstructive pulmonary disease: Moreover, an anti-CXCL8 blocking antibody also inhibited the increased migration induced by the secretions of CD8+ T cells purified from COPD tissues, in the same extend than the blocking of CXCR1/2 by reparixin (Figure 2F), suggesting that this supplementary chemotaxis is mainly due to CXCL8 and not other CXCR1/2 binding CXCL chemokines.