Since regions of microscopic emphysematous destruction of terminal bronchioles have been associated with increased infiltration of CD8+ T cells and immune response activation, such as the up-regulation of IFN-γ signaling (Xu et al., 2022), and we have evidenced fibrocyte-mediated cytotoxic activity in CD8+ T cells, it is tempting to speculate that fibrocyte-CD8+ T cell interplay could be implicated in early changes leading to tissue remodeling and chronic inflammation in COPD. The gene discussed is IFNG; the disease is chronic obstructive pulmonary disease.