Of the top ten pathways that were most significantly activated in co-cultured versus mono-cultured fibrocytes, the largest upregulated genes were those of the dendritic cell maturation box, the multiple sclerosis signaling pathway, the neuroinflammation signaling pathway, and the macrophage classical signaling pathway, irrespective of the activation state of CD8+ T cells (Figure 7B). Here, CD8A is linked to multiple sclerosis.