CD8A and chronic obstructive pulmonary disease: In agreement with previous studies (Dupin et al., 2019; O’Shaughnessy et al., 1997; Saetta et al., 1998), the density of both CD8+ T cells and fibrocytes was increased within the subepithelial area of distal bronchi from COPD patients compared with that of control subjects (Figure 1A–C).