The densities of CD8+ T cells in interaction with fibrocytes (Figure 8D), the mean minimal distances between fibrocytes and CD8+ cells (Figure 8E), the distribution of mean minimal distances (Figure 8—figure supplement 1), and the mean number of mixed cell clusters (Figure 8F) were in good agreement with tissular analyses and mimicked the variations observed between control subjects and patients with COPD. This evidence concerns the gene CD8A and chronic obstructive pulmonary disease.