GFAP and Alzheimer disease: Quantification revealed that both the overall CLU+ area and the CLU+GFAP+ area increased in C/C brains compared with that in T/T or C/T brains, with more dramatic increase in AD C/C brains than that in control C/C brains (Figures 7E, 7F, and 7G), supporting the idea that CLU expression is increased in C/C astrocytes compared with T/T or C/T astrocytes in human brains and increased in AD brains compared with that in control brains.