To evaluate whether the CLU rs11136000 variant is associated with white matter deficiency, healthy young adults were imaged to evaluate their white matter integrity in an imaging study.64 Of particular interest, healthy young adults who carry two copies of the risk “C” allele (C/C) of CLU rs11136000 exhibited reduced white matter integrity in multiple brain regions, including those involved in AD degeneration, compared with the “T” allele carriers.64 However, how the CLU risk allele causes myelination defects remains largely unknown. This evidence concerns the gene CLU and Alzheimer disease.