CLU and Alzheimer disease: To determine if elevated CLU and CXCL10 expression in C/C astrocytes occurs in human brains from CLU rs11136000 C/C carriers, we obtained brain tissues from C/C carriers, including non-demented (ND) control subjects or patients with AD, and included brain tissues from age and gender-matched T/T or C/T carrying ND subjects as controls (Table S5).