We performed three separate screens (Figure 4A) to capture the different mechanisms by which compounds modulate glucose uptake: (1) insulin-independent activation of GLUT4 translocation to the plasma membrane (basal activators), (2) potentiation of submaximal insulin action (insulin sensitisers), and (3) rescue of palmitate-induced insulin resistance (insulin resistance reversers). This evidence concerns the gene SLC2A4 and Insulin resistance.