Higher levels of C-reactive protein (CRP) [27, 28] and pro-inflammatory cytokines, including interleukin 6 (IL-6) [21, 27], interleukin 8 (IL-8) [21], interleukin 18 (IL-18) [29], and tumour necrosis factor (TNF-α) [21, 27, 30, 31] were found in the FF of women with PCOS when compared to ovulatory non-PCOS. This evidence concerns the gene TNF and polycystic ovary syndrome.