AKT1 and malignant colon neoplasm: Li et al. [49] indicated that abnormal activation of AKT and Ki-67 promoted colon cancer development and progression in addition to invasion and metastasis Considering the aforementioned data our results revealed a strong positive expression of Ki-67 in the tissues of rats with colon cancer which agree with the results of Xiao et al. [50] who conducted a noticeable upregulated expression of Ki-67 in mice with colorectal cancer induced by AOM-DSS.