Furthermore, the separation of Beclin-1 from the Bcl-2/Beclin-1 complex increased its levels leading not only to increasing the levels of LC3-B-induced autophagy [58] but also apoptosis in CRC via activation of the caspase-3 through the LC3 autophagy pathway [69]. The gene discussed is MAP1LC3A; the disease is colorectal carcinoma.