These results indicated that blocking of LMP1 by both LMP1-shRNA1 and 2 reduced the LMP1-induced immunosuppression in the NPC microenvironment, but the sequence-specific LMP1-shRNA2-mediated LMP1 blocking not only retained NPC-LMP1 cell immunogenicity but also provoked MHC-class I-dependent T cell recognition and specific cytotoxicity. The gene discussed is PDLIM7; the disease is nasopharyngeal carcinoma.