GCG and type 1 diabetes mellitus: To be clear, evidence for the autoimmune component in T1D remains strong, including the presentation of a moving 3D image of an nPOD donor (20-year-old T1D subject with 7 months disease duration) stained for glucagon and CD3, clearly demonstrating the presence of immune cells within the islet, interspersed amongst endocrine cells (Fig. 2).