MYD88 and neoplasm: Genomic characterization of WM tumor cells has identified recurrent somatic mutations in MYD88 (>95% patients) and CXCR4 (>30% patients) genes, and deletions involving chromosome 6q (del6q; ∼50% patients), among other alterations (Hunter et al., 2014; Schop et al., 2002; Treon et al., 2012).