Mechanistically, YAP/TAZ promote cancer EMT through inducing critical EMT-orchestrating transcriptional factors including TWIST, ZEB1, and snail family zinc finger 1/2 (Snail and Slug), which control the expression of EMT-associated gene profiles, such as those of E-cadherin, N-cadherin, vimentin, and matrix metalloproteinases. The gene discussed is YAP1; the disease is cancer.