Furthermore, dysregulation among genes including Nox4 (reviewed by (Chen et al., 2012)), Cx43 (reviewed by (Michela et al., 2015)), PGC1α (reviewed by (Oka et al., 2020)), VEGFA (reviewed by (Braile et al., 2020)), and TSP1 (reviewed by (Chistiakov et al., 2017)) are reported with increased risk of cardiovascular diseases. This evidence concerns the gene GJA1 and cardiovascular disorder.