(Curocichin et al., 2011; Dehghan et al., 2011; Eiriksdottir et al., 2009; Teng et al., 2009) Both serum CRP level and obesity play an important role in the risk assessment of cardiovascular diseases, therefore exploring the effect modification due to genetic factors and obesity could guide a personalized risk prediction. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.