Although missense mutations in MYH3 lead to several monoallelic musculoskeletal diseases such as Freeman–Sheldon syndrome, Sheldon–Hall syndrome, and multiple pterygium syndrome, the disorder where MYH3 mutations lead to partial or total loss of MyHC‐embryonic function is spondylocarpotarsal synostosis (Cameron‐Christie et al, 2018; Whittle et al, 2021; Kamien et al, 2022). Here, MYH6 is linked to Freeman-Sheldon syndrome.