And USP5 could regulate the stability of many tumorigenesis‐associated proteins, such as forkhead box M1 (FoxM1), MAF bZIP transcription factor (c‐Maf), Tu translation elongation factor, mitochondrial, and snail family transcriptional repressor 2 (SNAI2) to promote the cancer progression.42, 44, 60, 61. Here, USP5 is linked to cancer.