H2S reduces the promoter activity of Krüppel-like factor 5 (KLF5) and the expression of mRNA, and the S-sulfhydration of SP-1 by H2S at Cys664 weaken the activity of SP-1 and KLF5 promoter binding and inhibits cardiac hypertrophy.79 This evidence concerns the gene KLF5 and cardiac hypertrophy.