Memory impairment exists in several neurodegenerative diseases and is caused by a variety of pathological and physiological mechanisms, including neuroinflammation and aging.100, 101, 102 Interleukin-1β (IL-1β) is a pro-inflammatory factor widely found in the brain,103 postsynaptic density 95 (PSD95) is the core scaffold protein of the postsynaptic protein network, which is involved in the regulation of synaptic stability, strength, and plasticity.104. Here, IL1B is linked to memory impairment.