PPARG and obesity due to melanocortin 4 receptor deficiency: It enhanced the DNA binding activity of PPARγ response element promoter and promoted the expression of adipogenic gene, and the mutation of PPARγ at Cys139 site blocked the S-sulfhydration of H2S.53Protein tyrosine phosphatase 1B (PTP1B) plays an important role in endoplasmic reticulum (ER) stress and is thought to play an important role in obesity-induced cardiomyopathy and septic shock-induced cardiovascular dysfunction.54