ZFAS1 and malignant colon neoplasm: LncRNA ZFAS1 is a host gene of the SNORD12 family (SNORD12A, SNORD12B, and SNORD12C), which is highly expressed in various tumor tissues.27, 28, 29, 30 However, ZFAS1 maintains the methylation function of SNORD12C and SNORD78 by recruiting the SNP protein NOP58 as a scaffolding protein, thereby promoting the proliferation of colon cancer cells.31