DDX41 mutation is an important factor leading to MDS, and frameshift mutations at positions D52 and D140 of aspartic acid could lead to the inactivation of the DDX41 protein.112, 113, 114, 115, 116 DDX41, which belongs to the DEAD box protein family and is characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), is a putative RNA helicase. This evidence concerns the gene DDX41 and myelodysplastic syndrome.