PIEZO1 and dehydrated hereditary stomatocytosis: The presence of the PIEZO1 channel in human RBC membranes was first established from the link between gain-of-function mutations of PIEZO1 and a RBC pathology, termed Dehydrated Hereditary Stomatocytosis (DHS) or Xerocytosis (Zarychanski et al., 2012; Andolfo et al., 2013; Bae et al., 2013).