Top pathways associated with the development of ROP using the Lynx Enrichment tool include “HIF-1 signaling pathway,” “PI3K-Akt signaling pathway,” “angiogenesis,” “allograft rejection,” “SHP2 signaling,” and “Signaling events mediated by VEGFR1 and VEGFR2” (Figure 2). This evidence concerns the gene PTPN11 and retinopathy of prematurity.