Out of the 47 genes, 9 of these genes (Casp8, Atf4, Lgals1, Sema3A, Mir223, Malat1, TEAD4, Arg2, Sucnr1) were identified from animal studies of OIR models that noted a possible association to ROP. The gene discussed is CASP8; the disease is retinopathy of prematurity.