PDCD1 and neoplasm: In some MMRd hubs, T cells producing IFN gamma formed foci with interferon-stimulated genes (ISG) and CXCR3L expressing myeloid cells providing an environment conducive to lymphocyte recruitment, leading to infiltration of MMRd tumors by CXCL13+ T cells (a marker suggestive of tumor antigen reactive T cells (49–52)) and PDCD1 (PD-1)+ γδ-like T cells, which may increase the anti-tumor response.