(213) used an ovariectomy (OVX)-induced bone loss model in C57BL/6 mice to show that RTA-408 inhibits osteoclastogenesis and attenuates OVX-induced bone loss by inhibiting the STING-dependent NF-κB signaling pathway, suggesting that it may be a promising candidate for the future treatment of osteoporosis. The gene discussed is NFKB1; the disease is osteoporosis.